With 50K miles on the odometer, I have to say that of all cars I've owned the IS-350 has been the best. You ride in a solid car with over 300 ponies under the hood, Porsche 911 tires, steering characteristics of the SC-430 and technology of the 21st Century. From the precise steering to the rain sensing wipers, this car out-performs and delivers.
In the three years I've owned it (driving 90 miles per day for my work commute), the car visits the dealer frequently for scheduled maintanance only. Unlike Mercedes Benz, Lexus Service Centers are premium as for class and convenience (even offering computers with free Internet) and loaner vehicles if you want to leave the car and go to work.
My IS-350 has never malfunctioned and is just Gas & Go. In spite its relatively small six cylinder 350 cc engine, I achieve from 18 to an amazing 27 MPG on combined driving, depending on variables such as the number of occupants, how fast I need to be some place and the hills of Seattle. Changing the transmission mode to Power or Snow, decreases considerably the MPGs of the car. The steering mounted paddle shifters are awesome but beware of the cops.
I advice almost any Lexus enthusiast to test drive this vehicle. It's excellent except for those that need a useful rear seat (mine is suitable for chimpanzees only) and be adviced that even though the electronically controlled transmission has a Snow Mode, the car is not to be driven on icy roads; so much power in rear wheels makes too hard controlling the car. If you need these two features, consider the ES and you'll be saving plenty of bucks.
With this second generation IS platform, Lexus has been able to offer six different cars. The relatively inexpensive IS-250 (underpowered for my likes), the AWD model (great for snow but no power), the IS-F (with over 400 ponies, is like lithotripsy for your kidney stones) the new Coupe convertible; IS-C with a 250 or 350 engine (perhaps the best looking Lexus of all times) plus the well balanced IS-350.
I can only praise Toyota's Lexus division for such an extraordinary car and looking forward to what Lexus will offer us as replacement for the boring and bland looking current SC 430. Perhaps, its time to bring back a two seater like the MR-2. Batteries can be placed under the hood, the 1.8cc gas engine transversely on the trunk (driving the rear wheels, of course) and the classic removable roof panels. If Lexus can accomplish this, will feel sorry for Mercedes Benz. Hey guys from Lexus-Toyota, get the idea?