Desitin original with a purple label with overnight relief is my #1 diaper rash treatment choice. Desitin has other tubes with different colored labels. I have tried them with no effectiveness for my children. The purple label is the best by far. I couldn't tell you how many tubes of this product I purchased & still do. My kids are potty training & I use it still. Great item! Protects the skin from rash when applied regularly. The label says :helps provide overnight relief but I use it all the time. Rich & thick. Soothes & protects from diaper rash. Comes in small & large tubes. I always buy the large tube because I use so much of it. Contains 40% zinc oxide for skin protection. I always applied desitin to the bottom after each diaper change & especially before bed. The desitin will protect the bottom if babies wet during the night. Really works great. I can attest to it because my babies were rash free with this product. We want our babies to be as comfortable as possible through the day & during those long nights. A product you can count on!